Risk of Venous Thromboembolism (VTE)

Lifestyle FactorsCurrent Medical StatusMedical History
Increasing age

Increasing COC use

Personal/Family history of VTE

SmokingPregnancy/PostpartumInherited blood clotting disorders
ObesityMajor surgeryCancer
Immobilisation & High AltitudeMajor traumaOther medical conditions associated with VTE
  • The risk of VTE is highest in first year of Combined Hormonal Contraceptive use.1,2
  • The risk of VTE is increased when a Combined Hormonal Contraceptive is re-started after a break in use of 4 weeks or more.1,2
  • Combined hormonal contraceptives that contain levonorgestrel, norgestimate or norethisterone are associated with the lowest risk of VTE.1,2  Zoely may have a risk of VTE in the same range as observed with combined hormonal contraceptives containing levonorgestrel.3


  1. Faculty of Sexual & Reproductive Healthcare Statement Venous Thromboembolism (VTE) and Hormonal Contraception November 2014
  2. European Medicines Agency Benefits of combined hormonal contraceptives (CHCs) continue to outweigh risks – CHMP endorses PRAC recommendation November 2013 EMA/709120/2013
  3. Zoely® SPC Available at www.medicines.ie

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The information on this website is intended for patients who have been prescribed Zoely that reside in the Republic of Ireland or Malta only.

IE-ZOE-23(3) | Date of preparation: June 2022