Naturally Respectful

Natural Balance2 : Zoely is the first and only monophasic combined oral contraceptive with 24/4 regimen (28 tablets including 4 placebos) containing 1.5 mg estradiol combined with 2.5 mg nomegestrol acetate.

Nomegestrol acetate is a highly selective progestogen derived from the naturally occurring steroid hormone, progesterone. Nomegestrol acetate has a strong affinity for the human progesterone receptor and has an anti-gonadotropic activity, a progesterone receptor-mediated anti-oestrogenic activity, a moderate anti-androgenic activity, and is devoid of any oestrogenic, androgenic, glucocorticoid or mineralocorticoid activity1.

The oestrogen contained in Zoely is 17β-estradiol, a natural oestrogen identical to the endogenous human 17β-estradiol1.


  1. Zoely® Summary of Product Characteristics.
  2. Chabbert-Buffet N et al. Gynecol Endocrinol 2013; 29 (10): 891-6.
  3. Mashchak CA et al. Am J Obstet Gynecol, 1982, 144: 511-518.
  4. Lete I et al. Eur J Contracept Reprod Health Care 2015; 20 (5): 329-43.
  5. Cagnacci A et al. Eur J Contracept Reprod Health Care 2018; 23
  6. Lete I et al. Eur J Contracept Reprod Health Care 2015; 21 (4): 276-284

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